Recombinant Human HGF (Insect derived)
货号：100-39-10,100-39-100,100-39-1000,100-39-2,100-39-250,100-39-50,100-39-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1560,11439,45004,640,19659,6741,29196
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein containing 697 amino acid residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues. Recombinant Human HGF is an 80.0 kDa polypeptide consisting of 697 amino acid residues.来源:(BTI-Tn-5B1-4) Hi-5 Insect cells别名:Hepatocyte Growth Factor, Scatter Factor (SF), Hepatopoietin (HPTA)氨基酸序列:alpha chain:QRKRRNTIHE FKKSAKTTLI KIDPALKIKT KKVNTADQCA NRCTRNKGLP FTCKAFVFDK ARKQCLWFPF NSMSSGVKKE FGHEFDLYEN KDYIRNCIIG KGRSYKGTVS ITKSGIKCQP WSSMIPHEHS FLPSSYRGKD LQENYCRNPR GEEGGPWCFT SNPEVRYEVC DIPQCSEVEC MTCNGESYRG LMDHTESGKI CQRWDHQTPH RHKFLPERYP DKGFDDNYCR NPDGQPRPWC YTLDPHTRWE YCAIKTCADN TMNDTDVPLE TTECIQGQGE GYRGTVNTIW NGIPCQRWDS QYPHEHDMTP ENFKCKDLRE NYCRNPDGSE SPWCFTTDPN IRVGYCSQIP NCDMSHGQDC YRGNGKNYMG NLSQTRSGLT CSMWDKNMED LHRHIFWEPD ASKLNENYCR NPDDDAHGPW CYTGNPLIPW DYCPISRCEG DTTPTIVNLD HPVISCAKTK QLRbeta chain:VVNGIP TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP NRPGIFVRVA YYAKWIHKII LTYKVPQS纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells. The expectedED50for this effect is 1.0-20.0 ng/ml.Calculated Molecular Weight:80 kDaAccession Number:P14210Gene ID:3082交叉反应:Dog,Human,Human + Mouse,Leech,Monkey,Mouse,Mouse + Human,Rabbit,Rat原产国：USA |
product.subtitle.recentcitations |
第一作者 | Cordero-Espinoza, L |
标题 | Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation. |
文献引用 | Cell Stem Cell; |
PubMed Id | 34343491 |
第一作者 | Meseguer-Ripolles, J |
标题 | Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure. |
文献引用 | Iscience; 24(6) pg102552 |
PubMed Id | 34151225 |
第一作者 | Ebisudani, T |
标题 | Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening. |
文献引用 | Cell Reports; 35(10) pg109218 |
PubMed Id | 34038715 |
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