PD0325901
货号：04-0006
规格：2 mg
价格：0
产品类型：小分子化合物
品牌：Stemgent
PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation1,2. Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells3.
产品详情
| Size | 2 mg (Cat. No. 04-0006) |
| 10 mg (Cat. No. 04-0006-10) |
| ChemicalName | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Chemical Formula | C16H14F3IN2O4 |
| Molecular Weight | 482.19 |
| CAS Number | 391210-10-9 |
| Purity | Greater than 97% by HPLC analysis |
| Formulation | Pale purple solid |
| Solubility | Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet. |
| Storage and Stability | Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. |
| Quality Control | The purity of PD0325901 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observedin mouse embryonic stem cells following a 6 hour exposure to 1 nM - 100 µM of PD0325901. |
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参考文献
Bain, J., Plater, L., Elliott, M., Hastie, C.J., McLauchlan, H., Klevernic, I., Arthur, J.S., Alessi, D.R., and Cohen, P. (2007) The selectivity of protein kinase inhibitors: a further update.Biochem. J. 408: 297-315.
Sebolt-Leopold, J.S. and Herrera, R. (2004) Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947.
Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., Lin, X., Hahm, H.S., Hao, E., Hayek, A., and Ding, S. (2009) A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808.
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