Recombinant Human IGF-BP5
货号：100-05-100,100-05-1000,100-05-25,100-05-250,100-05-5,100-05-500
规格：100ug,1mg,25ug,250ug,5ug,500ug
价格：6404,25699,1425,11205,585,16653
产品类型：细胞因子添加物
品牌：PeproTech
| 别名:Insulin-like Growth Factor-Binding Protein 5, IBP-5描述:IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa, cysteine-rich, secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts, and osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5-overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition, and retarded muscle development. Recombinant Human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.氨基酸序列:MLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQSCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ VKIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDRRKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKYGM KLPGMEYVDG DFQCHTFDSS NVS来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is ≤ 0.3 μg/ml in the presence of 15 ng/ml of human IGF-II.交叉反应:Human原产国:USA仅用于研究。不适用于诊断或治疗。 |
product.subtitle.recentcitations |
第一作者 | Yamada, K |
标题 | Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling. |
文献引用 | Scientific Reports; 6 pg21410 |
PubMed Id | 26887791 |
第一作者 | Martino, M M |
标题 | Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. |
文献引用 | Proceedings of the National Academy of Sciences of the United States of America; 110(12) pg4563-8 |
PubMed Id | 23487783 |
第一作者 | Francischetti, I M |
标题 | Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin. |
文献引用 | PLoS ONE; 5(2) pge9356 |
PubMed Id | 20195466 |
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