Recombinant Human Epiregulin
货号：100-04-100,100-04-1000,100-04-25,100-04-5,100-04-500,100-04-250
规格：100ug,1mg,25ug,5ug,500ug,250ug
价格：6410,25699,1425,585,16653,11205
产品类型：细胞因子添加物
品牌：PeproTech
| 别名：EREG描述:Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant Human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence.氨基酸序列:MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105units/mg.交叉反应:小鼠、人类 |
| product.subtitle.recentcitations |
| 第一作者 | Choi, N |
| 标题 | Epiregulin promotes hair growth via EGFR-medicated epidermal and ErbB4-mediated dermal stimulation. |
| 文献引用 | Cell Proliferation; pge12881 |
| PubMed Id | 32700456 |
| 第一作者 | Ho, J |
| 标题 | Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. |
| 文献引用 | Nature Communications; 10(1) pg2297 |
| PubMed Id | 31127085 |
| 第一作者 | Junk, D J |
| 标题 | Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. |
| 文献引用 | Oncogene; 36(28) pg4001-4013 |
| PubMed Id | 28288136 |
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