Animal-Free Recombinant Rat GDNF
货号：AF-450-51-10,AF-450-51-100,AF-450-51-1000,AF-450-51-2,AF-450-51-250,AF-450-51-50,AF-450-51-500
规格：10µg,100ug,1mg,2ug,250ug,50ug,500ug
价格：2830,21940,87780,1250,38400,13160,57050
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Rat GDNF is 30.0 kDa.Manufactured using all Animal-Free reagents.来源:E.coli别名:Glial-Derived Neurotrophic Factor, ATF-1氨基酸序列:MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCEAAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDSLV YHILRKHSAK RCGCI纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to stimulate the proliferation of rat C6 cells.Calculated Molecular Weight:30 kDaAccession Number:Q07731Gene ID:254535原产国:USA |
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