Recombinant Human TGF-β2 (Insect derived)
货号：100-35-10,100-35-100,100-35-1000,100-35-2,100-35-250,100-35-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：1568,12235,48997,643,21395,31787
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2-dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immunosurveillance of tumor development. Recombinant Human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.来源:(BTI-Tn-5B1-4) Hi-5 Insect cells别名:Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin氨基酸序列: ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS 纯度:≥ 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. TheED50was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106units/mg.Calculated Molecular Weight:25 kDaAccession Number:P61812Gene ID:7042交叉反应:Chicken,Human,Human + Virus,Mouse,Rat,Sheep原产国：USA |
product.subtitle.recentcitations |
第一作者 | Hanson, M G |
标题 | Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. |
文献引用 | The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71 |
PubMed Id | 9736656 |
第一作者 | Xu, W W |
标题 | Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis. |
文献引用 | Advanced science (Weinheim, Baden-Wurttemberg, Germany); 7(16) pg2000925 |
PubMed Id | 32832354 |
第一作者 | Beel, S |
标题 | κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis |
文献引用 | Nature Communications; 11(1) pg3409 |
PubMed Id | 32641778 |
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