Recombinant Human sTNF Receptor Type II
货号：310-12-100,310-12-1000,310-12-20,310-12-250,310-12-5,310-12-500
规格：100ug,1mg,20ug,250ug,5ug,500ug
价格：6379,25574,1418,11161,582,16588
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α, but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α-induced activities by acting as a decoy receptor. The human TNFRII gene encodes for a 461 amino acid type I transmembrane protein, which contains a 22 amino acid signal sequence, a 235 amino acid extracellular domain, a 30 amino acid transmembrane domain, and a 174 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type II is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine-rich, ligand binding portion of the extracellular domain of the TNFRII protein.来源:E.coli别名:soluble Tumor Necrosis Factor Type II, TNFRSF1B, TNFR75, p75, CD120b, TNFR80, p80, TNFR2氨基酸序列:MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. TheED50for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-α, is 0.125 µg/ml.Calculated Molecular Weight:18.9 kDaAccession Number:P20333Gene ID:7133交叉反应：Human,Mouse,Rat原产国:USA |
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