Recombinant Human LIGHT
货号：310-09B-100,310-09B-1000,310-09B-15,310-09B-250,310-09B-3,310-09B-500
规格：100ug,1mg,15ug,250ug,3ug,500ug
价格：8506,34097,1418,14890,582,22118
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activateNF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. The human LIGHT gene encodes for a 240 amino acid type II transmembrane protein containing a 37 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 182 amino acid extracellular domain. Recombinant Human LIGHT has a calculated mass of 19.3 kDa, containing 177 amino acid residues. Due to glycosylation, LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions.*Human LIGHT(Catalog Number 310-09B) has replaced Human LIGHT(Catalog Number 310-09)来源:Hi-5 Insect cells别名:TNFSF14, HVEM-L氨基酸序列:RLGEMVTRLP DGPAGSWEQL IQERRSHEVN PAAHLTGANS SLTGSGGPLL WETQLGLAFL RGLSYHDGAL VVTKAGYYYI YSKVQLGGVG CPLGLASTIT HGLYKRTPRY PEELELLVSQ QSPCGRATSS SRVWWDSSFL GGVVHLEAGE KVVVRVLDER LVRLRDGTRS YFGAFMV纯度:≥ 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to induce IL-8 secretion in human BEAS-2B cells.Calculated Molecular Weight:19.3 kDaAccession Number:O43557Gene ID:8740原产国:USA |
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