Recombinant Murine Neuropoietin
货号：250-25B-100,250-25B-1000,250-25B-25,250-25B-250,250-25B-5,250-25B-500
规格：100ug,1mg,25ug,250ug,5ug,500ug
价格：8003,33403,1425,14593,585,21676
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex formed of a CNTF receptor-α component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons, and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human neuropoietin gene has evolved toward a pseudogene, suggesting that alternative signaling via CNTF is an effective compensatory pathway. Recombinant Murine Neuropoietin is a 19.8 kDa protein containing 183 amino acid residues.来源:E.coli别名:NPO, NP氨基酸序列:MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 μg/ml.Calculated Molecular Weight:19.8 kDaAccession Number:P83714Gene ID:244218 |
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