Anti-Mouse TNF-Alpha APC

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Anti-Mouse TNF-Alpha APC

货号:84422-80-50,84422-80-100

规格:50 ug,100 ug

价格:1815,3300

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :84422-80

Description

The MP6-XT22 monoclonal antibody specifically reacts with mouse tumor necrosis factor alpha (TNF-alpha), a 156 amino pro-inflammatory cytokine. It is secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. NF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MP6-XT22 is reported to neutralize the bioactivity of natural or recombinant TNF-alpha and is useful for intracellular immunofluorescent staining.

Additional Information

Clone

MP6-XT22

Format:

APC

Applications

FC

Reactivity

Mouse

Isotype:

Rat IgG1, kappa

Research Interest:Innate Immunity,Apoptosis
Cell Type:T Cells,Monocytes and Macrophages,NK and NKT Cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Abrams, J. S. (1995). Immunoenzymetric assay of mouse and human cytokines using NIP‐labeled anti‐cytokine antibodies.Current Protocols in Immunology, 6-20.

Williams, R. O., Mauri, C., Mason, L. J., Marinova‐Mutafchieva, L., Ross, S. E., Feldmann, M., & Maini, R. N. (1998). Therapeutic actions of cyclosporine and anti‐tumor necrosis factor α in collagen‐induced arthritis and the effect of combination therapy.Arthritis & Rheumatism,41(10), 1806-1812.

Litton, M. J., Remington, J. S., & Abrams, J. S. (1994). Immunocytochemical detection of cytokines in the lymph nodes and brains of mice resistant or susceptible to toxoplasmic encephalitis.Journal of Infectious Diseases,170(4), 939-945.

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