Anti-Mouse Foxp3 FITC

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Anti-Mouse Foxp3 FITC

货号:83412-50-25,83412-50-100

规格:25ug,100 μg

价格:2027,3064

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :83412-50

Description

The 3G3 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression.

Mutations of Foxp3 result in the “scurfy” mice phenotype.

Additional Information

Clone

3G3

Format:

FITC

Applications

FC

Reactivity

Mouse

Isotype:

Mouse IgG1, kappa

Research Interest:Adaptive Immunity
Cell Type:T Cells,Treg cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Nagar, M., Vernitsky, H., Cohen, Y., Dominissini, D., Berkun, Y., Rechavi, G., ... & Goldstein, I. (2008). Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25− CD4+ T cells.International immunology,20(8), 1041-1055.

Bolzer, K., Käser, T., Saalmüller, A., & Hammer, S. E. (2009). Molecular characterisation of porcine Forkhead-box p3 (< i> Foxp3</i>).Veterinary immunology and immunopathology,132(2), 275-281.

Gavin, M. A., Torgerson, T. R., Houston, E., Ho, W. Y., Stray-Pedersen, A., Ocheltree, E. L., ... & Rudensky, A. Y. (2006). Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.Proceedings of the National Academy of Sciences,103(17), 6659-6664.

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