Anti-Mouse IL-12/IL-23 p40 PE

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Anti-Mouse IL-12/IL-23 p40 PE

货号:83312-60-25,83312-60-100

规格:25ug,100 μg

价格:833,2216

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :83312-60

Description

The C17.8 antibody specifically reacts with the p40 subunit of IL-12, as free monomer, as a homodimer, or as a part of the p70 dimer. C17.8 seems to neutralize the activity of mouse IL-12 and IL-23. IL-12 is the p70 heterodimer of p35 and p40, expressed by the macrophages, dendritic cells, and monocytes. The C17.8 antibody cross-reacts with IL-23, since IL-23 also contains one p40 subunit.

Additional Information

Clone

C17.8

Format:

PE

Applications

FC

Reactivity

Mouse

Isotype:

Rat IgG2a, kappa

Research Interest:Innate Immunity
Cell Type:Dendritic Cells,Monocytes and Macrophages,T Cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Wysocka, M., Kubin, M., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P., & Trinchieri, G. (1995). Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice.European journal of immunology,25(3), 672-676.

Cho, D., Lee, W. J., Halloran, P. J., Trinchieri, G., & Kim, Y. B. (1996). Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12.Cellular immunology,172(1), 29-34.

D'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste, M., ... & Nickbarg, E. (1992). Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.The Journal of experimental medicine,176(5), 1387-1398.

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