Anti-Mouse IL-1 alpha SAFIRE Purified-Bio-Rad-Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱

Anti-Mouse IL-1 alpha SAFIRE Purified

2024-10-15

Anti-Mouse IL-1 alpha SAFIRE Purified

货号：82312-25

规格：500 μg

价格：3410

产品类型：抗体和染料

品牌：Biogems

物种：人

宿主：小鼠

抗体亚型：IgG

荧光染料：Purified

Catalogue Number :82312-25

Description

IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. The ALF-161 monoclonal antibody reacts with the precursor, secreted and membrane-associated forms of mouse IL-1 α. The antibody is reported to be usable as the capture antibody in an ELISA assay and exhibits neutralization properties.

Additional Information

Clone	ALF-161
Format:	SAFIRE Purified
Applications	FA, FC, Neutralization
Reactivity	Mouse
Isotype:	Armenian Hamster IgG
Research Interest:	Adaptive Immunity,Innate Immunity
Cell Type:	Monocytes and Macrophages
Preperation:	The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:	Phosphate-buffered aqueous solution, ph7.2.
References:	Shibuya, K., Robinson, D., Zonin, F., Hartley, S. B., Macatonia, S. E., Somoza, C., ... & O’Garra, A. (1998). IL-1α and TNF-α are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice.The Journal of Immunology,160(4), 1708-1716. Fuhlbrigge, R. C., Sheehan, K. C., Schreiber, R. D., Chaplin, D. D., & Unanue, E. R. (1988). Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity.The Journal of Immunology,141(8), 2643-2650. Beckerman, K. P., Rogers, H. W., Corbett, J. A., Schreiber, R. D., McDaniel, M. L., & Unanue, E. R. (1993). Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.The Journal of Immunology,150(3), 888-895.

技术参数

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