Anti-Mouse KLRG1 PE

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Anti-Mouse KLRG1 PE

货号:82112-60-25,82112-60-100

规格:25 μg,100 μg

价格:778,2333

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :82112-60

Description

The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen). The antigen contains a cytoplasmic motif similar to ITIM (the immunoreceptor tyrosine-based inhibitory motif). KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence. The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes. It is expressed on lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, a sub-set of natural killer (NK) cells, T cells. In NK cells, it inhibits cytokine production and cytotoxicity activity.

The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.

Additional Information

Clone

2F1

Format:

PE

Applications

FC

Reactivity

Mouse

Isotype:

Golden Syrian Hamster IgG

Research Interest:Innate Immunity,Adaptive Immunity
Cell Type:NK and NKT Cells,T Cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Beyersdorf, N. B., Ding, X., Karp, K., & Hanke, T. (2001). Expression of inhibitory" killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells.European journal of immunology,31(12), 3443-3452.

Corral, L., Hanke, T., Vance, R. E., Cado, D., & Raulet, D. H. (2000). NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules.European journal of immunology,30(3), 920-930.

Robbins, S. H., Terrizzi, S. C., Sydora, B. C., Mikayama, T., & Brossay, L. (2003). Differential regulation of killer cell lectin-like receptor G1 expression on T cells.The Journal of Immunology,170(12), 5876-5885.

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