Anti-Mouse CD284 (TLR4) PE

2024-10-16

Anti-Mouse CD284 (TLR4) PE

货号:26912-60

规格:25 μg

价格:1430

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :26912-60

Description

The UT41 monoclonal antibody specifically reacts with mouse CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). The complex of TLR-4, MD-2, and CD14 regulates the innate immune system recognition of bacterial lipopolysaccharides (LPS) and is expressed on the surface of thioglycollate-elicited macrophages. The UT41 antibody can bind to TLR4 with or without the formation of the TLR4/MD-2 complex.

Additional Information

Clone

UT41

Format:

PE

Applications

FC

Reactivity

Mouse

Isotype:

Mouse IgG1

Research Interest:

Innate Immunity

Cell Type:

Monocytes and Macrophages

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Yang, D., Liu, Y., Chen, Y., Jiao, D., Hou, X., Wang, L., & Fu, N. (2012). Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.International journal of molecular medicine,29(6), 1072.

Nomura, F., Akashi, S., Sakao, Y., Sato, S., Kawai, T., Matsumoto, M., ... & Akira, S. (2000). Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.The Journal of Immunology,164(7), 3476-3479.

Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Mühlradt, P. F., Takeda, K., & Akira, S. (2000). Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways.The Journal of Immunology,165(12), 7096-7101.

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