Anti-Mouse CD115 (c-fms) SAFIRE Purified

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Anti-Mouse CD115 (c-fms) SAFIRE Purified

货号:17212-25-100,17212-25-500

规格:100 μg,500 μg

价格:1839,3685

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :17212-25

Description

The AFS98 monoclonal antibody specifically reacts with the mouse CD115 molecule, a 150 kDa receptor for the colony stimulating factor (CSF-1) or macrophage CFS (M-CFS), expressed by some epithelial cells, monocytes, osteoclasts, and macrophages. The colony stimulating factor-1 regulates the proliferation and the differentiation of the monocytic lineage cells.

The AFS98 antibody can be used to identify myeloid lineage cells.

Additional Information

Clone

AFS98

Format:

SAFIRE Purified

Applications

FC, FA, WB

Reactivity

Mouse

Isotype:

Rat IgG2a, kappa

Research Interest:Innate Immunity,Angiogenesis
Cell Type:Monocytes and Macrophages

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Murayama, T., Yokode, M., Kataoka, H., Imabayashi, T., Yoshida, H., Sano, H., ... & Kita, T. (1999). Intraperitoneal administration of anti–c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E–deficient mice.Circulation,99(13), 1740-1746.

Sudo, T., Nishikawa, S., Ogawa, M., Kataoka, H., Ohno, N., Izawa, A., & Hayashi, S. (1995). Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M.Oncogene,11(12), 2469-2476.

Yoshino, M., Yamazaki, H., Yoshida, H., Niida, S., Nishikawa, S. I., Ryoke, K., ... & Hayashi, S. I. (2003). Reduction of osteoclasts in a critical embryonic period is essential for inhibition of mouse tooth eruption.Journal of Bone and Mineral Research,18(1), 108-116.

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