Anti-Human CD152 (CTLA-4) PE

admin 2024-10-16 34

Anti-Human CD152 (CTLA-4) PE

货号:14611-60-25,14611-60-100

规格:25 tests,100 tests

价格:943,2263

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :14611-60

Description

The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.

Additional Information

Clone

BNI3

Format:

PE

Applications

FC

Reactivity

Human

Isotype:

Mouse IgG2a, kappa

Research Interest:Adaptive Immunity
Cell Type:T Cells,Treg cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., & van der Merwe, P. A. (1997).The leucocyte antigen factsbook. Academic Press.

Lindsten, T., Lee, K. P., Harris, E. S., Petryniak, B., Craighead, N., Reynolds, P. J., ... & Gray, G. S. (1993). Characterization of CTLA-4 structure and expression on human T cells.The Journal of Immunology,151(7), 3489-3499.

Kuiper, H. M., Brouwer, M., Linsley, P. S., & Van Lier, R. A. (1995). Activated T cells can induce high levels of CTLA-4 expression on B cells.The Journal of Immunology,155(4), 1776-1783.

技术参数
© Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价,请加客服QQ:1749072012 、客服微信:jinshanbio,或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务,数据资源基于CC协议。
© 本文地址:https://biorod.cn/thread-15787.htm
产品询价需求提交
最新回复 (0)
返回
发布信息
扫码添加客服微信,咨询产品报价