Anti-mouse CD49b (Integrin alpha 2) SAFIRE Purified

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Anti-mouse CD49b (Integrin alpha 2) SAFIRE Purified

货号:11512-25

规格:50 ug

价格:1210

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalog Number :11512-25

Description

The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1). VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.

Additional Information

Clone

HMa2

Format:

SAFIRE Purified

Applications

FC, FA

Reactivity

Mouse

Isotype:

Armenian Hamster IgG

Research Interest:Adaptive Immunity,Angiogenesis
Cell Type:T Cells,Monocytes and Macrophages,NK and NKT Cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Arase, H., Saito, T., Phillips, J. H., & Lanier, L. L. (2001). Cutting edge: the mouse NK cell-associated antigen recognized by DX5 moncoclonal antibody is CD49b (α2 integrin, very late antigen-2).The Journal of Immunology,167(3), 1141-1144.

Miyake, S., Sakurai, T., Okumura, K., & Yagita, H. (1994). Identification of collagen and laminin receptor integrins on murine T lymphocytes.European journal of immunology,24(9), 2000-2005.

Noto, K., Kato, K., Okumura, K., & Yagita, H. (1995). Identification and functional characterization of mouse CD29 with a mAb.International immunology,7(5), 835-842.

技术参数
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