Anti-Mouse CD18 SAFIRE Purified

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Anti-Mouse CD18 SAFIRE Purified

货号:10212-25 -50,10212-25 -100,10212-25-500

规格:50 ug,100 ug,500 ug

价格:1100,1925,3410

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalog Number :10212-25

Description

The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein. CD18 is expressed on all leukocytes with the highest density by NK and T cells. CD18 forms LFA-1 with CD11a, Mac-1 with CD11b and gp150/95 with CD11c. Through these interactions, CD18 has an important role in cellular adhesion. The M18/2 antibody is reported to stimulate Mac-1 and LFA-1 adhesion to their ligands and block tumor cell metastasis.

Additional Information

Clone

M18/2

Format:

SAFIRE Purified

Applications

FC, FA

Reactivity

Mouse

Isotype:

Rat IgG2a, kappa

Research Interest:Angiogenesis
Cell Type:T Cells,NK and NKT Cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Driessens, M. H., Van Hulten, P., Zuurbier, A., La Riviere, G., & Roos, E. (1996). Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1,-2, and-3 are distinct.Journal of leukocyte biology,60(6), 758-765.

Zahalka, M. A., & Naor, D. (1994). β2-lntegrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness.International immunology,6(6), 917-924.

Isobe, M., Yagita, H., Okumura, K., & Ihara, A. (1992). Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1.Science,255(5048), 1125-1127.

技术参数
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