| Description: The HIB19 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane glycoprotein. CD19 is expressed by B cells during all stages of development excluding the terminally differentiated plasma cells. Follicular dendritic cells also express CD19. Together CD21, CD81, Leu13, MHC class II, and CD19 form a multimolecular complex that associates with BCR. Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells. The SJ25C1 antibody and the HIB19 monoclonal antibody recognize overlapping epitopes.Applications Reported: The HIB19 antibody has been reported for use in flow cytometric analysis.Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered. |
| 1.Nature cell biologyMedial HOXA genes demarcate haematopoietic stem cell fate during human development.View published figure on By clicking the link above, you will be redirected to the Benchsci website. Disclaimer2.BiogerontologyDevelopment of depressive symptoms post hip fracture is associated with altered immunosuppressive phenotype in regulatory T and B lymphocytes.2016"12-0199 was used in Flow cytometry/Cell sorting to investigate whether hip fracture and depressive symptoms had additive effects upon the aged immune system."Authors Duggal NA,Upton J,Phillips AC,Lord JM3.VirulenceAntibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death."12-0199 was used in Flow cytometry/Cell sorting to demonstrate that PSGL-1 present on the cell surfaces of monocyte-derived dendritic cells mediates enterovirus 71 binding and facilitates further infection."Authors Ren XX,Li C,Xiong SD,Huang Z,Wang JH,Wang HB4.CytotherapyPhenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study.2015"12-0199 was used in Flow cytometry/Cell sorting to determine whether chronic inflammation affects precursor number or the phenotype of monocyte-derived macrophages."Authors Moore JK,Mackinnon AC,Wojtacha D,Pope C,Fraser AR,Burgoyne P,Bailey L,Pass C,Atkinson A,Mcgowan NW,Manson L,Turner ML,Campbell JD,Forbes SJ5.Journal of neuroinflammationInterleukin-22 is increased in multiple sclerosis patients and targets astrocytes.2015"12-0199 was used in Flow cytometry/Cell sorting to characterise the role of IL-22 in the context of multiple sclerosis."Authors Perriard G,Mathias A,Enz L,Canales M,Schluep M,Gentner M,Schaeren-Wiemers N,Du Pasquier RA |
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