Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitution in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Physical form

Lyophilized from 10 mM acetic acid. The protein may appear as a haze or film, which is difficult to see at the bottom of the vial.

Biochem/physiol Actions

Stromal Cell-Derived Factor-1α (SDF-1α) is a pleiotropic chemokine. It works as a chemoattractant for T- and B-lymphocytes and inflammatory monocytes. In neural stem cells, SDF-1α is needed for proliferation, survival, migration, intercellular interaction and guidance to neuronal axon. It is responsible for pathogenic inflammation in the central nervous system (CNS).[1] It also controls BMP (bone morphogenic protein)-associated osteogenic differentiation.[2]

General description

Stromal Cell-Derived Factor-1α (SDF-1α) is a recently discovered protein belonging to the α-chemokine (C-X-C) family of cytokines.[3] Recombinant mouse SDF-1α is a 7.9kDa protein containing 68 amino acids residues.