ANTI-HUMAN CD38 (HB7) EFLUOR 450
货号：48-0388-41,48-0388-42
规格：25TESTS,100TESTS
价格：0,2380
产品类型：流式抗体
品牌：eBioscience
抗原：CD38
物种：人
宿主：小鼠
抗体亚型：IgG
克隆号：HB7
荧光染料：eFluor 450
| 抗体类型: | 单抗 | 同型对照： | IgG1, kappa |
| 免疫原性： | | 用法： | 5uL（0.06 µg）/test(Flow） |
| Description: The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. CD38 is an ectoenzyme which catalyses NAD into nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR), both of which are secondary messengers. Expression of CD38 is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. Additionally CD38 is found in a variety of tissues and other hematopoietic cells (e.g. T cells, NK cells and monocytes) and can be used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38- population of hematopoietic stems cells is thought to define the most pluripotent cells (e.g. blast colony forming cells). In addition to surface expression, CD38 has recently been found in the nucleus where it may play a role in monitoring calcium levels.Applications Reported: This HB7 antibody has been reported for use in flow cytometric analysis.Applications Tested: This HB7 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.Filtration: 0.2 µm post-manufacturing filtered. |
| 数据 |
CD38 Antibody (48-0388-41) in FlowStaining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control eFluor® 450 (Product # 48-4714-82) (blue histogram) or Anti-Human CD38 eFluor® 450 (purple histogram). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.Journal of cellular biochemistryCD38 is constitutively expressed in the nucleus of human hematopoietic cells.Authors Orciani M,Trubiani O,Guarnieri S,Ferrero E,Di Primio R2.BloodAnti-CD38-blocked ricin: an immunotoxin for the treatment of multiple myeloma.Authors Goldmacher VS,Bourret LA,Levine BA,Rasmussen RA,Pourshadi M,Lambert JM,Anderson KC3.BloodSequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells.Authors Terstappen LW,Huang S,Safford M,Lansdorp PM,Loken MR4.Journal of immunology (Baltimore, Md. : 1950)Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.Authors Jackson DG,Bell JI |
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