CD29 (Integrin beta 1) Monoclonal Antibody (eBioHMb1-1 (HMb1-1)), FITC, eBioscience™
货号：11-0291-80,11-0291-82
规格：25 µg,100 µg
价格：643,1627
产品类型：流式抗体
品牌：eBioscience
抗原：CD29
物种：人/小鼠/大鼠
宿主：Armenian hamster仓鼠
抗体亚型：IgG
克隆号：eBioHMb1-1 (HMb1-1)
荧光染料：FITC
| 类型: | 单抗 | 同型对照： | Armenian Hamster IgG Isotype Control (eBio299Arm), FITC |
| 浓度： | 0.5 mg/mL | 用法： | 1 µg/test(Flow） |
产品详细信息Description: The eBioHMb1-1 monoclonal antibody reacts with mouse and rat CD29 (integrin beta 1), a 110-120 kDa member of the beta integrin family expressed by leukocytes, endothelial, smooth muscle and epithelial cells. CD29 binds non-covalently with the alpha integrins CD49a-f to form the VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. All integrins which include CD29 bind to extracellular matrix proteins including collagen, laminin, fibronectin and vitronectin, whereas some CD29-containing integrins can also interact with cellular receptors such as VCAM-1 and MadCAM-1.Applications Reported: This eBioHMb1-1 (HMb1-1) antibody has been reported for use in flow cytometric analysis.Applications Tested: This eBioHMb1-1 (HMb1-1) antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins. ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component ofvarious protein complexes binding to extracellular matrix proteins. Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue. Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta. More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. The distribution pattern in adult tissues for integrin beta types are mutually exclusive. Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.
| 数据 |
| CD29 (Integrin beta 1) Antibody (11-0291-80) in FlowStaining of C57Bl/6 bone marrow cells with Anti-Human/Mouse CD45R (B220) APC(Product # 17-0452-82) and 0.5 µg of Armenian Hamster IgG Isotype Control FITC(Product # 11-4888-81) (left) or 0.5 µg of Anti-Mouse/Rat CD29 (Integrin beta 1) FITC (right).Cells in the small scatter population were used for analysis. |
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| 参考文献： |
| 1.The Journal of clinical investigationFOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.View published figure on By clicking the link above, you will be redirected to the Benchsci website. Disclaimer2.PloS oneMicrogrooved-surface topography enhances cellular division and proliferation of mouse bone marrow-derived mesenchymal stem cells.View published figure on By clicking the link above, you will be redirected to the Benchsci website. Disclaimer3.Experimental and therapeutic medicineTreatment of radiation-induced acute intestinal injury with bone marrow-derived mesenchymal stem cells.View published figure on By clicking the link above, you will be redirected to the Benchsci website. Disclaimer4.Molecular therapy oncolyticsPreclinical evaluation of VAX-IP, a novel bacterial minicell-based biopharmaceutical for nonmuscle invasive bladder cancer.View published figure on By clicking the link above, you will be redirected to the Benchsci website. Disclaimer5.Proceedings of the National Academy of Sciences of the United States of AmericaCasitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.View published figure on By clicking the link above, you will be redirected to the Benchsci website. Disclaimer |
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