CD140b (PDGFRB) Monoclonal Antibody (APB5), APC, eBioscience™
货号：17-1402-80,17-1402-82
规格：25 µg,100 µg
价格：1205,3157
产品类型：流式抗体
品牌：eBioscience
抗原：CD140b (PDGFRB)
物种：小鼠
宿主：大鼠
抗体亚型：IgG
克隆号：APB5
荧光染料：APC
| 抗体类型: | 单抗 | 同型对照： | IgG2a, kappa |
| 免疫原性： | | 用法： | 0.5 µg/test(Flow） |
Description: The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the beta chain of the platelet derived growth factor receptor (PDGF receptor). PDGFRb is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding and phosphorylates substrates. Dimers of PDGFR consist of either homodimers of alpha/alpha, beta/beta, or heterodimers of alpha/beta and serve as a substrate for its kinase activity. CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. The PDGFR beta chain is reported to play a significant role in formation of fibrous atherosclerotic lesions.Applications Reported: This APB5 antibody has been reported for use in flow cytometric analysis.Applications Tested: This APB5 antibody has been tested by flow cytometric analysis of NIH 3T3 cell line. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationPDGFRb is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
| 数据 |
| CD140b (PDGFRB) Antibody (17-1402-80) in FlowStaining of the NIH/3T3 cell line with 0.25 µg of Rat IgG2a kappa Isotype Control APC(Product # 17-4321-81) (blue histogram) or 0.25 µg of Anti-Mouse CD140b (PDGF Receptor b)APC (purple histogram). Total viable cells were used for analysis. |
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| 参考文献： |
| 1.Molecular metabolismNeonatal pancreatic pericytes support β-cell proliferation.2.Stem cell research and therapyLaminin differentially regulates the stemness of type I and type II pericytes.3.PloS oneIsoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart....4.Scientific reportsAnalysis of the brain mural cell transcriptome.5.The Journal of biological chemistryFibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases. |
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