CD44var (v5) Monoclonal Antibody (VFF-8), eBioscience™

货号：BMS115

规格：100 µg

价格：1959

产品类型：流式抗体

品牌：eBioscience

抗原：CD44var (v5)

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：VFF-8

荧光染料：其它

抗体类型:	单抗	同型对照：	IgG1
免疫原性：		用法：

Description: Specifically recognizes an epitope encoded by exon v5 on the variant portion of human CD44.Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.Applications Tested: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blotting.Purity: >95%.Background/Target InformationCD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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参考文献：

1.Nucleic acids researchAlternative splicing of CNOT7 diversifies CCR4-NOT functions."BMS115 was used in Western Blotting to report that CNOT7 variant 2 (CNOT7v2) displays a distinct expression profile and a nuclear sub-cellular localisation, when compared to CNOT7v1."AuthorsChapat C,Chettab K,Simonet P,Wang P,De La Grange P,Le Romancer M,Corbo L

技术参数

产品应用 Flow；WB；IHC (P)

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