CD31 (PECAM-1) Monoclonal Antibody (390), Biotin, eBioscience™

货号：13-0311-81,13-0311-82,13-0311-85

规格：50 ug,100 ug,500 ug

价格：838,1267,2944

产品类型：流式抗体

品牌：eBioscience

物种：小鼠

宿主：大鼠

抗体亚型：其它

克隆号：390

荧光染料：PE

抗体类型:	单抗	同型对照：	Rat IgG2a kappa Isotype Control, Biotin, eBioscience™
免疫原性：		用法：	0.25 μg/test(Flow)

Product Specific InformationDescription: The 390 monoclonal antibody reacts with mouse CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on all leukocytes and platelets. It has been reported that CD38 binds to CD31. Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction.Applications Reported: The 390 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 390 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationCD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

Surface staining of mouse splenocytes with Anti-Mouse CD31 (PECAM-1) FITC (left), and PE (right). Autofluorescence is shown via open histogram. Total viable cells were used for analysis.

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参考文献：

Immunology and cell biology T-cell response to herpes simplex virus-1. By clicking the link above, you will be redirected to the Benchsci website. Nature communications Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours. "13-0311 was used in Flow cytometry/Cell sorting to investigate how p53 deficiency contributes to breast tumourigenesis from luminal cells." AuthorsTao L,Xiang D,Xie Y,Bronson RT,Li Z

技术参数

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