Indomethacin

货号：73942

规格：1g

价格：582

产品类型：小分子化合物

品牌：STEMCELL Technologies

DescriptionIndomethacin is a non-steroidal, anti-inflammatory agent that inhibits cyclooxygenase (COX) activity, thereby blocking the production of prostaglandins (Vane et al.). Indomethacin inhibits both COX-1 and COX-2 (IC50 = 0.08 and 0.96 µM for recombinant human COX-1 and COX-2, respectively; Kurumbail et al.).DIFFERENTIATION· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.).· Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).CANCER RESEARCH· Inhibits growth of mouse mammary tumors (Fulton).· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).Alternative Names:IndocinCAS Number:53-86-1Chemical Formula:C₁₉H₁₆ClNO face="Cambria Math">₄Molecular Weight:357.8 g/molPurity:≥ 99%Pathway:NF-κBTarget:COX-1

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