CD4 Monoclonal Antibody (OKT4 (OKT-4)), eFluor 660
货号：50-0048-41,50-0048-42
规格：25 Tests,100 Tests
价格：1112,2534
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG2b, kappa
荧光染料：eFluor 660
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG2b kappa Isotype Control (eBMG2b), eFluor 660 |
| 浓度： | 5 µL/Test | 用法： | 5 μL (0.03 μg)/test(Flow) |
| 产品详细信息Description: The OKT4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by the majority of thymocytes, a subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). The OKT4 antibody recognizes a different epitope than the RPA-T4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes.Applications Reported: This OKT4 (OKT-4) antibody has been reported for use in flow cytometric analysis.Applications Tested: This OKT4 (OKT-4) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.03 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017]. |
| 数据 |
| CD4 Antibody (50-0048-41) in FlowStaining of normal human peripheral blood cells with Mouse IgG2b K Isotype Control eFluor® 660 (Product # 50-4732-82) (blue histogram) or Anti-Human CD4 eFluor® 660 (purple histogram). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.BloodCD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface."Published figure using CD4 monoclonal antibody (Product # 50-0048-42) in Flow Cytometry"2.PloS oneAn increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma."Published figure using CD4 monoclonal antibody (Product # 50-0048-42) in Immunohistochemistry"3.BloodCD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface."Published figure using CD4 monoclonal antibody (Product # 50-0048-42) in Flow Cytometry"4.Nature communicationsExpression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab."Published figure using CD4 monoclonal antibody (Product # 50-0048-42) in Flow Cytometry"5.Nature communicationsLineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm."50-0048 was used in Flow cytometry/Cell sorting to demonstrate that a plasmacytoid dendritic cell-specific super-enhancer of RUNX2 is associated with the MYC promoter due to t(6;8)."AuthorsKubota S,Tokunaga K,Umezu T,Yokomizo-Nakano T,Sun Y,Oshima M,Tan KT,Yang H,Kanai A,Iwanaga E,Asou N,Maeda T,Nakagata N,Iwama A,Ohyashiki K,Osato M,Sashida G |
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