ABCA4 Polyclonal Antibody

货号：PA5-78688

规格：100 µg

价格：2746

产品类型：免疫组化一抗

品牌：eBioscience

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

类型:	多抗	同型对照：
浓度：		用法：	0.1-0.5 µg/mL(WB)
免疫原性：	A synthetic peptide corresponding to a sequence at the C-terminus of human ABCA4.

产品详细信息The synthetic peptide sequence is 1890-1927aa, FLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRAdd 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.靶标信息ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.

数据

ABCA4 Antibody (PA5-78688) in WBWestern blot analysis of ABCA4 in rat eye extract (lane 1) and mouse eye extract (lane 2). Sample was incubated with ABCA4 polyclonal antibody (Product # PA5-78688) at a dilution of 0.5 µg/mL. Signal development was performed using a chemiluminescence (ECL) kit.

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