ABCA4 Polyclonal Antibody

货号：PA5-87983

规格：100 µL

价格：4732

产品类型：免疫组化一抗

品牌：eBioscience

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

类型:	多抗	同型对照：
浓度：	5.26 mg/mL	用法：	1：50-1：200 (IF);1：1000-1：2000(WB)
免疫原性：	Recombinant fusion protein containing a sequence corresponding to amino acids 110-300 of human ABCA4

产品详细信息Immunogen sequence: QELLMNAPES QHLGRIWTEL PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ; Positive Samples: U-251MG, BT-474, 293T, Mouse heart, Mouse lung, Rat eye; Cellular Location: Membrane, Multi-pass membrane protein靶标信息ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.

数据

ABCA4 Antibody (PA5-87983) in WBWestern blot analysis of extracts of various cell lines, using ABCA4 Polyclonal antibody (Product # PA5-87983) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 10s. ABCA4 Antibody (PA5-87983) in IFImmunofluorescence analysis of HeLa cells using ABCA4 Polyclonal antibody (Product # PA5-87983) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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