beta-3 Tubulin Monoclonal Antibody (2G10-TB3), Alexa Fluor 488, eBioscience™
货号：53-4510-80,53-4510-82
规格：25 µg,100 µg
价格：1735,4322
产品类型：免疫组化一抗
品牌：eBioscience
物种：人/小鼠/大鼠
宿主：小鼠
抗体亚型：IgG2a, kappa
荧光染料：Purified
类型: | 单抗 | 同型对照： | |
浓度： | 0.5 mg/mL | 用法： | 10 µg/mL (ICC)；10 µg/mL (IF)；Assay Dependent（IHC(P)）；Assay Dependent（IHC(F)） |
免疫原性： | |
产品详细信息
Description: The 2G10 monoclonal antibody recognizes beta tubulin class III, a member of the large family of tubulins that are components of the microtubules of the cytoskeletal network. Beta tubulin class III expression is exclusively found in neuronal cells of adult mammals. Although expression has been mainly found in neuronal cells, during fetal development, transient expression has been documented in both glial and neuronal precursors localized to the subventricular zone. Identification of beta tubulin class III expression is useful as a structural marker for developing and mature neural cells. Given the high degree of conservation of this protein across species, the 2G10 clone is expected to recognize human, mouse, rat, and bovine beta tubulin class III.Applications Reported: This 2G10-TB3 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry.Applications Tested: This 2G10-TB3 antibody has been tested by immunocytochemistry of formaldehyde-fixed and permeabilized cells and can be used at less than or equal to 10 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
The betaIII-tubulin isoform is present dominantly in cells of neuronal origin and it is one of the earliest markers of neuronal differentiation. It is regarded as a specific probe for the cells of neuronal origin as well as for the tumours originating from these cells. The betaIII-tubulin is most abundant in cells of neuronal origin, but was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.
数据 |
| beta-3 Tubulin Antibody (53-4510-82) in ICC Immunocytochemistry of fixed and permeabilized SK-N-SH cells using 10 µg/mL Anti-Beta Tubulin Class III Alexa Fluor® 488. Nuclei are stained with DAPI. |
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| 二抗荧光二抗免疫组化一抗标签抗体 |
| 参考文献： |
| 1.Molecular autism Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders. |
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