Pdx1 Monoclonal Antibody (2A12), eFluor 660, eBioscience™

货号：50-6500-82

规格：100 µg

价格：0

产品类型：免疫组化一抗

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgG

荧光染料：Purified

类型:	单抗	同型对照：
浓度：	0.2 mg/mL	用法：	Assay Dependent (ICC)；Assay Dependent (IF)；20 µg/mL（IHC(P)）
免疫原性：

产品详细信息Description: This 2A12 monoclonal antibody reacts with the transcriptional activator PDX1, also known as pancreatic and duodenal homeobox protein and insulin promoter factor. Early expression of PDX1 during development marks the endoderm from which the pancreas, stomach, and duodenum derive. In the mature pancreas, expression is found in insulin-expressing beta-cells. PDX1 functions as an important regulator of several key pancreatic proteins including insulin, somatostatin, glucokinase, islet amyloid factor, and glucose transporter type 2. Deficiency in PDX1 results in a dysregulation of the beta-cell compensation of insulin resistance, which can lead to late-onset type 2 diabetes mellitus (formerly NIDDM) and maturity onset diabetes of the young type 4 (MODY4).Applications Reported: This 2A12 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry.Applications Tested: This 2A12 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 20 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

数据

Pdx1 Antibody (50-6500-82) in IF Immunohistochemistry of formalin-fixed paraffin embedded human pancreas stained with 20 µg/mL Mouse IgG1 K Isotype Control eFluor® 660 (left) or 20 µg/mL Anti-Human PDX1 eFluor® 660 (right). Nuclei are stained with DAPI.

二抗荧光二抗免疫组化一抗标签抗体

参考文献：

技术参数

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