AFP Recombinant Polyclonal Antibody (9HCLC)
货号： 710486
规格：100 µg
价格：4809
产品类型：免疫组化一抗
品牌：eBioscience
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：Purified
类型: | 多抗 | 同型对照： | |
浓度： | 0.5 mg/mL | 用法： | 1-2 µg/mL (ICC)；1-2 µg/mL (IF)；1:50-1:500（IHC (P)）；1-2 µg/mL (WB) |
免疫原性： | Peptide corresponding to amino acids 149–161 and 430–440 of human Alpha-fetoprotein |
产品详细信息Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. 靶标信息AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract and the liver during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of AFP may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric, dimeric, and trimeric forms. AFP can also bind to copper ions, nickel ions, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. High level of serum AFP has been identified in patients with hepatocellular carcinomas (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.
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| AFP Antibody (710486) in IF Immunofluorescent analysis of alpha Fetoprotein in HeLa cells using an Alpha Fetoprotein Recombinant Rabbit Polyclonal Antibody (Product # 710486) followed by detection using an Alexa Fluor 488-conjugated Goat anti-Rabbit secondary antibody (green). |
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| 二抗荧光二抗免疫组化一抗标签抗体 |
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