Applications

FA

Synonyms:

RG-108, RG 108, CHEMBL1564869, NCI401077

Formulation:

Crystalline solid

Chemical Name:

(2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

Molecular Formula:

C₁₉H₁₄N₂O₄

Molecular Weight:

334.3

CAS Number

48208-26-0

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Schirrmacher, E., Beck, C., Brueckner, B., Schmitges, F., Siedlecki, P., Bartenstein, P., ... & Schirrmacher, R. (2006). Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases.Bioconjugate chemistry,17(2), 261-266.

Asgatay, S., Champion, C., Marloie, G., Drujon, T., Senamaud-Beaufort, C., Ceccaldi, A., ... & Guianvarc’h, D. (2014). Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.Journal of medicinal chemistry,57(2), 421-434.

Shi, Y., Desponts, C., Do, J. T., Hahm, H. S., Schöler, H. R., & Ding, S. (2008). Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.Cell stem cell,3(5), 568-574.