CD34 Monoclonal Antibody (581), FITC

2024-10-17

CD34 Monoclonal Antibody (581), FITC

货号:CD34-581-01

规格:500μl

价格:3227

产品类型:流式抗体

品牌:Thermo Fisher

物种:人

宿主:小鼠

抗体亚型:IgG

克隆号:581

荧光染料:FITC

抗体类型:单抗同型对照:IgG1
免疫原性:用法:5 µL for 1x10^6 cells(Flow)

靶标信息CD34是高度糖基化的单体111-115 kDa表面蛋白,存在于许多干细胞群体中。 CD34是干细胞标记,尽管其在人类造血干细胞上的表达是可逆的。 CD34可用作表面受体,该表面受体经历受体介导的内吞作用并调节造血干细胞和其他祖细胞的粘附,分化和增殖。 CD34表达可能代表造血细胞发育的特定状态,在体外和体内条件下,其粘附特性都可能发生改变,并具有扩大和分化的能力。 CD34可能是一种粘附分子,可能具有介导干细胞附着于骨髓细胞外基质或直接附着于基质细胞的作用。此外,CD34可以作为支架用于谱系特异性聚糖的附着,从而使干细胞与基质细胞或其他骨髓成分表达的凝集素结合。 CD34被认为在向选择素呈递碳水化合物配体中起作用。 CD34抗原的细胞内链是被活化的蛋白激酶C磷酸化的位点,提示在信号转导中可能发挥了作用。与CD34功能障碍有关的疾病包括皮肤纤维肉瘤和神经纤维瘤。

推荐产品:
流式抗体细胞周期检测细胞凋亡检测细胞增殖活性检测
参考文献:
1. The Journal of steroid biochemistry and molecular biologyOxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death."CD34-581-01 was used in flow cytometry to research adipose tissue-derived mesenchymal stem cell proliferation and death with oxysterols"AuthorsSilva SF,Levy D,Ruiz JLM,de Melo TC,Isaac C,Fidelis ML,Rodrigues A,Bydlowski SP2. CytotherapyAnalysis of the safety of mesenchymal stromal cells secretome for glioblastoma treatment."CD3458101 was used in flow cytometry to assess the use of human adipose-derived stem cells to treat cancer"AuthorsOnzi GR,Ledur PF,Hainzenreder LD,Bertoni AP,Silva AO,Lenz G,Wink MR3. PloS oneMesenchymal stem cells augment the anti-bacterial activity of neutrophil granulocytes."CD34-581-01 was used in flow cytometry to study the effect of mesenchymal stem cells on the anti-bacterial activity of neutrophil granulocytes"AuthorsBrandau S,Jakob M,Bruderek K,Bootz F,Giebel B,Radtke S,Mauel K,Jäger M,Flohé SB,Lang S4. Stem cell research and therapyThe bidirectional tumor--mesenchymal stromal cell interaction promotes the progression of head and neck cancer."CD34-581-01 was used in flow cytometry to isolate and characterize mesenchymal stromal cells from head and neck squamous cell carcinoma and study their interaction with tumor cells"AuthorsKansy BA,Dißmann PA,Hemeda H,Bruderek K,Westerkamp AM,Jagalski V,Schuler P,Kansy K,Lang S,Dumitru CA,Brandau S5. The Journal of clinical investigationAntigen CD34+ marrow cells engraft lethally irradiated baboons."CD34-581-01 was used in flow cytometry to propose that stem cells responsible for hematopoietic reconstitution are CD34+"AuthorsBerenson RJ,Andrews RG,Bensinger WI,Kalamasz D,Knitter G,Buckner CD,Bernstein ID

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