LYVE1 Human ELISA Kit/人LYVE1 ELISA试剂盒
货号：EHLYVE1,EHLYVE1X5,EHLYVE1X10
规格：96 tests,5X96 tests,10X96 tests
价格：7238,30186,53584
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 8 pg/mL |
| 检测范围 | 8.19-2000 pg/mL |
样本类型/体积 | 上清液 100 μL 血清 1 μL 血浆 1 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 分析稀释浓缩液 - 生物素化检测抗体 -SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | LYVE1 |
| Protein aliases | cell surface retention sequence binding protein-1, Cell surface retention sequence-binding protein 1, CRSBP-1, extracellular link domain containing 1, extracellular link domain-containing 1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | CRSBP-1, CRSBP1, HAR, LYVE-1, LYVE1, UNQ230/PRO263, XLKD1 |
| Gene ID | (Human) 10894 |
| Gene symbol | LYVE1 |
| UniProt ID | (Human) Q9Y5Y7 |
| The Human LYVE1 ELISA quantitates Hu LYVE1 in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu LYVE1.人LYVE1 ELISA可以定量人血清，血浆或细胞培养基中的人LYVE1。 该检测试剂盒将只识别天然和重组人 LYVE1。Principle of the method 方法原理The Human LYVE1 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.人LYVE1固相夹心ELISA（酶联免疫吸附测定）设计用于测量匹配的抗体对之间结合的靶标量。 已在提供的微孔板的孔中预包被了靶标特异性抗体。 然后将样品，标准液或质控品添加到这些孔中，并与固定的（捕获）抗体结合。 通过添加第二（检测）抗体形成三明治，添加底物溶液，该底物溶液与酶-抗体-靶标复合物反应以产生可测量的信号。 该信号的强度与原始样品中存在的靶标浓度成正比。Rigorous validation 严格验证Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.此ELISA试剂盒的每个制造批次均经过质量测试，其标准包括敏感性，特异性，精密度和批次间一致性。 有关验证的更多信息，请参见手册。Target information 靶标信息LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 is a type I integral membrane glycoprotein. LYVE-1 is expressed primarily on lymphatic vessel endothelium and is likely to be involved in regulating the traffic of leucocytes and tumor cells to lymph nodes. The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. A number of molecules have been identified as markers for lymphatic endothelium which include LYVE1, PALE, VEGFR3, and podoplanin. Diseases associated with LYVE1 dysfunction includes Complete Androgen Insensitivity Syndrome.LYVE1已被确定为淋巴管壁上HA（细胞外基质糖胺聚糖透明质酸）的主要受体。推导的LYVE1氨基酸序列预测与CD44 HA受体相似，具有322个残基的I型整合膜多肽41％，具有212个残基的胞外域，其中包含一个Link模块，即Link蛋白超家族的原型HA结合域。像CD44一样，LYVE1分子结合可溶性和固定化HA。然而，与CD44不同，LYVE1分子与HA在淋巴管壁腔表面共定位，并且在血管中完全不存在。因此，LYVE1是第一个被表征的淋巴特异性HA受体，并且是淋巴管自身的独特强大标记。 LYVE1是I型整合膜糖蛋白。 LYVE-1主要在淋巴管内皮细胞上表达，并参与调节白细胞和肿瘤细胞向淋巴结的运输。淋巴管系统形成了第二个循环系统，该循环系统从组织中排出细胞外液，并提供了一个独特的环境，免疫细胞可以在该环境中遇到并响应外来抗原。已经鉴定出许多分子作为淋巴管内皮细胞的标志物，包括LYVE1，PALE，VEGFR3和Podoplanin。与LYVE1功能障碍有关的疾病包括完全雄激素不敏感综合症。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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