CD9 Recombinant Rabbit Monoclonal Antibody (SA35-08)/CD9 重组兔单抗 (SA35-08)
货号：MA5-31980
规格：100 µL
价格：4732
产品类型：免疫组化一抗
品牌：Thermo Fisher
抗原：C terminal Human CD9
物种：人/小鼠/大鼠
宿主：兔
抗体亚型：IgG
克隆号：SA35-08
荧光染料：其它
| 类型: | 重组单抗 | 同型对照： | IgG |
| 浓度： | 1 mg/mL | 用法： | 1:20-1:50（Flow）;1:50-1:200(ICC);1:50-1:200(IF);1:50-1:200(IHC);1:500-1:1,000(WB) |
产品详细信息Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.靶标信息CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.
数据 |
| CD9 Antibody (MA5-31980) in IHC (P)Immunohistochemical analysis of CD9 of paraffin-embedded Human tonsil tissue using a CD9 Monoclonal antibody (Product #MA5-31980). Counter stained with hematoxylin. |
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