CD9 Monoclonal Antibody (MM2/57)/CD9单抗 (MM2/57)
货号：MA1-80307
规格：100 µg
价格：4880
产品类型：免疫组化一抗
品牌：Thermo Fisher
抗原：Human platelet membrane.
物种：人/小鼠
宿主：小鼠
抗体亚型：其它
克隆号：MM2/57
荧光染料：其它
类型: | 单抗 | 同型对照： | IgG2b |
浓度： | 1 mg/mL | 用法： | 1/100 - 1/200(Flow);1/500 - 1/1000(IHC (F)) |
产品详细信息Predicted to react with mustelid based on sequence homology.For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.Mouse anti Human CD9 antibody, clone MM2/57 recognizes human leukocyte antigen MIC3 also known as MRP-1 or CD9.靶标信息CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.
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参考文献： |
| 1.OncotargetCD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.2.PloS oneStatins decrease lung inflammation in mice by upregulating tetraspanin CD9 in macrophages.3.Molecular biology of the cellTetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis.4.The Journal of biological chemistryDouble deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.5.Cancer researchCD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. |
QQ:1749072012