CD9 Monoclonal Antibody (EM-04)/CD9单抗(EM-04)
货号：MA1-10309
规格：100 µg
价格：2180
产品类型：免疫组化一抗
品牌：Thermo Fisher
抗原：Permeabilized murine bone marrow-derived mast cell
物种：小鼠
宿主：大鼠
抗体亚型：IgG
克隆号：EM-04
荧光染料：其它
类型: | 单抗 | 同型对照： | IgG |
浓度： | 1 mg/mL | 用法： | 4 µg/mL(Flow);1 µg/mL(WB) |
靶标信息CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.
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