CD63 Recombinant Rabbit Monoclonal Antibody (SY21-02)/CD63 重组兔单抗 (SY21-02)

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CD63 Recombinant Rabbit Monoclonal Antibody (SY21-02)/CD63 重组兔单抗 (SY21-02)

货号:MA5-32085

规格:100 µL

价格:4732

产品类型:免疫组化一抗

品牌:Thermo Fisher

抗原:Human CD63 aa 100-200

物种:人

宿主:兔

抗体亚型:IgG

克隆号:SY21-02

荧光染料:其它

类型:

单抗

同型对照:

IgG

浓度:

1 mg/mL

用法:

1:50-1:200(IHC);1:1,000(WB)

产品详细信息Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.靶标信息CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

数据

CD63 Antibody (MA5-32085) in IHC (P)Immunohistochemical analysis of CD63 of paraffin-embedded Human lung cancer tissue using a CD63 Monoclonal antibody (Product #MA5-32085). Counter stained with hematoxylin.

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