CD81 Recombinant Rabbit Monoclonal Antibody (SN206-01)/CD81 重组兔单抗(SN206-01)

货号：MA5-32333

规格：100 µL

价格：4732

产品类型：免疫组化一抗

品牌：Thermo Fisher

抗原：Human TAPA1 aa 150-250

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

克隆号：SN206-01

荧光染料：其它

类型:	单抗	同型对照：	IgG
浓度：	1 mg/mL	用法：	1:50-1:100(Flow);1:100-1:500(ICC);1:100-1:500(IF);1:50-1:200(IHC);1:1,000-1:2,000(WB)

产品详细信息Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.靶标信息CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.

数据

CD81 Antibody (MA5-32333) in IHC (P)Immunohistochemical analysis of CD81 of paraffin-embedded Human liver tissue using a CD81 Monoclonal antibody (Product #MA5-32333). Counter stained with hematoxylin.

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