CD81 Monoclonal Antibody (1.3.3.22)/CD81 单抗 (1.3.3.22)

货号：MA5-13548

规格：500 µL

价格：4880

产品类型：免疫组化一抗

品牌：Thermo Fisher

抗原：B cell line derived from a Burkitt lymphoma

物种：人

宿主：小鼠

抗体亚型：其它

克隆号：1.3.3.22

荧光染料：其它

类型:	单抗	同型对照：	IgG1, kappa
浓度：	0.2 mg/mL	用法：	1:10-1:100(ICC);1:10-1:100(IF);1:100-1:500(WB)

产品详细信息MA5-13548 targets CD81 in WB, FACS, FN, ICC/IF, and IHC (F) applications and shows reactivity with Human and Rat samples.The MA5-13548 immunogen is b cell line derived from a Burkitt lymphoma.靶标信息CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.

数据

CD81 Antibody (MA5-13548) in IHCFrozen human tonsil stained with CD81 antibody using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of lymphocytes.

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参考文献：

1.Frontiers in molecular neuroscienceInflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke.2.PloS oneHuman embryonic stem cells extracellular vesicles and their effects on immortalized human retinal Müller cells.

技术参数

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