IL-6 Monoclonal Antibody (MQ2-13A5)

货号：14-7069-81,14-7069-85

规格：50μg,500μg

价格：1175,3353

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：大鼠

抗体亚型：IgG

克隆号：MQ2-13A5

荧光染料：其它

类型:	单抗	同型对照：
浓度：	0.5 mg/mL	用法：	2-8 µg/mL(ELISA)

产品详细信息Description: The MQ2-13A5 antibody reacts with human interleukin-6 (IL-6), a 21-28 kDa cytokine secreted by a variety of cell types.Applications Reported: The MQ2-13A5 antibody has been reported for use in capture of human IL-6 by ELISA, intracellular staining for flow cytometric analysis, and for neutralizing IL-6 bioactivity.Applications Tested: The MQ2-13A5 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of human Interleukin-6 (IL-6) in combination with the biotin MQ2-39C3 (13-7068) antibody for detection and recombinant human IL-6 (14-8069) as the standard. A suitable range of concentrations of this antibody for ELISA capture is 2-8 µg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloidprogenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.

数据

FIGURE 1/7IL-6 Antibody (14-7069-85)Stem cells (Dayton, Ohio) 2017 -Published figure using IL-6 monoclonal antibody (Product # 14-7069-85)

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参考文献：

1.PLoS pathogensDengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components."14-7069 was used in an ELISA assay to evaluate the relative contributions of inflammatory mediators and endothelial cell-intrinsic pathways in Dengue virus."AuthorsGlasner DR,Ratnasiri K,Puerta-Guardo H,Espinosa DA,Beatty PR,Harris E2.Proceedings of the National Academy of Sciences of the United States of AmericaBiallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.3.Clinical and vaccine immunology : CVIToll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis."14-7069 was used in an ELISA assay to investigate the differences between Salmonella enterica strains in terms of TLR activation by generalised modules for membrane antigens from lipid A mutants."

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