CD41a Monoclonal Antibody (HIP8), FITC

货号：11-0419-41,11-0419-42

规格：25 Tests,100 Tests

价格：822,2112

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：HIP8

荧光染料：FITC

类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC
浓度：	5 µL/Test	用法：	5 μL (0.25 μg)/test(Flow)

产品详细信息Description: The HIP8 monoclonal antibody reacts with the human CD41 molecule, the integrin alphaIIb also known as platelet GPIIb. CD41 non-covalently associates with integrin beta3 (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. HIP8 blocks platelet aggregation.Applications Reported: The HIP8 antibody has been reported for use in flow cytometric analysis.Applications Tested: This HIP8 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

数据

CD41a Antibody (11-0419-41) in FlowStaining of human platelets with Anti-Human CD42b APC and Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (left) or Anti-Human CD41a FITC (right). Total events were used for analysis.

推荐产品：

二抗荧光二抗免疫组化一抗标签抗体

参考文献：

1.Nature communicationsThe role of platelets in mediating a response to human influenza infection."11-0419 was used in Immunocytochemistry-immunoflourescence to determine if platelet processes are activated during influenza infection."AuthorsKoupenova M,Corkrey HA,Vitseva O,Manni G,Pang CJ,Clancy L,Yao C,Rade J,Levy D,Wang JP,Finberg RW,Kurt-Jones EA,Freedman JE2.Nature communicationsThe role of platelets in mediating a response to human influenza infection."11-0419 was used in Immunocytochemistry-immunoflourescence to determine if platelet processes are activated during influenza infection."AuthorsKoupenova M,Corkrey HA,Vitseva O,Manni G,Pang CJ,Clancy L,Yao C,Rade J,Levy D,Wang JP,Finberg RW,Kurt-Jones EA,Freedman JE3.OncotargetPD-L1 is expressed on human platelets and is affected by immune checkpoint therapy."11-0419 was used in Flow cytometry/Cell sorting to demonstrate the expression and upregulation of PD-L1 on platelets and peripheral blood mononuclear cells from smokers and patients with head and neck squamous cell carcinoma or lung cancer."AuthorsRolfes V,Idel C,Pries R,Plötze-Martin K,Habermann J,Gemoll T,Bohnet S,Latz E,Ribbat-Idel J,Franklin BS,Wollenberg B4.Experimental and therapeutic medicineAssociation between toll-like receptor 6 expression and auxiliary T cells in the peripheral blood of pediatric patients with allergic purpura."11-0419 was used in Flow cytometry/Cell sorting to investigate the correlations between Toll-like receptor 6 expression in the peripheral blood mononuclear cells and auxiliary T cells of children with purpura."AuthorsChang H,Cao Y,Lin YI,Zhu H,Fu Y,Chen X,Zhang Q5.Journal of lipid researchCirculating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies."11-0419 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism by which anti-OxLDL IgM antibodies could mediate protective functions in CVD."AuthorsTsiantoulas D,Perkmann T,Afonyushkin T,Mangold A,Prohaska TA,Papac-Milicevic N,Millischer V,Bartel C,Hörkkö S,Boulanger CM,Tsimikas S,Fischer MB,Witztum JL,Lang IM,Binder CJ

技术参数

© Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://biorod.cn/thread-22310.htm