A 83-01

货号：9094360-10,9094360-25

规格：10 mg,25 mg

价格：978,1816

产品类型：小分子化合物

品牌：PeproTech

描述:A 83-01 is a potent activing receptor-like kinase inhibitor (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM). It is a more potent inhibitor of ALK5 than SB 431542 and is reported to inhibit Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. However, A 83-01 had little or no effect on bone morphogenetic protein type I receptors, p38 mitogen-activated protein kinase, or extracellular regulated kinase. It is used to inhibit differentiation in iPSCs and maintain in vitro cellular self-renewal.同义词A-83-01, A83-01, ALK5 Inhibitor IV, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083

技术参数

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