CD49b (Integrin alpha 2) Monoclonal Antibody (HMa2), FITC

货号：11-0491-81,11-0491-82

规格：50μg,100μg

价格：0,1545

产品类型：流式抗体

品牌：eBioscience

物种：小鼠

宿主：Armenian hamster仓鼠

抗体亚型：IgG

克隆号：HMa2

荧光染料：FITC

类型:	单抗	同型对照：	Armenian Hamster IgG Isotype Control (eBio299Arm), FITC
浓度：	0.5 mg/mL	用法：	0.125 μg/test(Flow)

产品详细信息Description: The HMalpha2 monoclonal antibody reacts with mouse CD49b, the 150 kDa integrin alpha2 subunit. The complex of CD49b non-covalently associated with integrin beta1 (CD29), also known as VLA-2, is a receptor for collagen and laminin. This complex is expressed by some CD4^+ T cells, IEL, NK cells, platelets and epithelial cells.Applications Reported: The HM alpha2 antibody has been reported for use in flow cytometric analysis.Applications Tested: The HM alpha2 antibodyhas been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles inVEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

数据

CD49b (Integrin alpha 2) Antibody (11-0491-81) in FlowStaining of mouse splenocytes with 0.06 µg of Armenian Hamster IgG Isotype Control FITC (Product # 11-4888-81) (open histogram) or 0.06 µg of Anti-Mouse CD49b (Integrin alpha 2) FITC (filled histogram). Total viable cells were used for analysis.

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参考文献：

1.Journal of cellular and molecular medicineCytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy."11-0491 was used in Flow cytometry/Cell sorting to provide evidence correlating the deleterious effects of blocking CYP26A1 in pregnancy with the aberrant regulation of NK cells in the uterus."2.Cellular and molecular immunologyThe breast tumor microenvironment alters the phenotype and function of natural killer cells."11-0491 was used in Flow cytometry/Cell sorting to investigate the developmental stage of tumour-associated NK cells, showing that the tumour microenvironment alters the phenotype and function of NK cells."3.Parasites and vectorsMulticomponent LBSap vaccine displays immunological and parasitological profiles similar to those of Leish-Tec® and Leishmune® vaccines against visceral leishmaniasis."11-0491 was used in Flow cytometry/Cell sorting to compare the effects of the multicomponent LBSap vaccine with those of Leish-Tec® and Leishmune®."Authorsde Mendonça LZ,Resende LA,Lanna MF,Aguiar-Soares RD,Roatt BM,Castro RA,Batista MA,Silveira-Lemos D,Gomes Jde A,Fujiwara RT,Rezende SA,Martins-Filho OA,Corrêa-Oliveira R,Dutra WO,Reis AB,Giunchetti RC4.PloS oneDecrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis."11-0491 was used in Flow cytometry/Cell sorting to analyse the expression of the inhibitory natural killer receptor NKG2A on T cells in a mouse colitis model and human inflammatory bowel disease."AuthorsKatsurada T,Kobayashi W,Tomaru U,Baba T,Furukawa S,Ishizu A,Takeda K,Sakamoto N,Asaka M,Takeda H,Kasahara M5.PloS oneMacrophages help NK cells to attack tumor cells by stimulatory NKG2D ligand but protect themselves from NK killing by inhibitory ligand Qa-1."11-0491 was used in Flow cytometry/Cell sorting to examine the role of the interaction between natural killer cells and macrophages in the regulation of the anti-tumour activities of natural killer cells."AuthorsZhou Z,Zhang C,Zhang J,Tian Z

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