CD71 (Transferrin Receptor) Monoclonal Antibody (R17217 (RI7 217.1.4)), FITC

货号：11-0711-81,11-0711-82,11-0711-85

规格：50μg,100μg,500μg

价格：967,1599,3092

产品类型：流式抗体

品牌：eBioscience

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：CD71 (Transferrin Receptor) Monoclonal Antibody (R

荧光染料：FITC

类型:	单抗	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), FITC
浓度：	0.5 mg/mL	用法：	0.5 μg/test(Flow)

产品详细信息Description: The R17217 monoclonal antibody reacts with mouse CD71, a 170-180 kDa type II transmembrane protein. CD71, the transferrin receptor, exists as a homodimer on the cell surface and is essential for cellular growth. CD71 is expressed by immature proliferating cells and at low levels on resting mature lymphocytes. Antigen or mitogen stimulation of T and B cells upregulates the expression of CD71. Expression level differences have been observed in different mouse strains.Applications Reported: The R17217 antibody has been reported for use in flow cytometric analysis.Applications Tested: This R17217 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means ofdetecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

数据

CD71 (Transferrin Receptor) Antibody (11-0711-81) in FlowStaining of C57Bl/6 bone marrow cells with Anti-Human/Mouse CD45R (B220) APC (Product # 17-0452-82) and 0.25 µg of Rat IgG2a K Isotype Control FITC (Product # 11-4321-42) (left) or 0.25 µg of Anti-Mouse CD71 (Transferrin Receptor) FITC (right). Cells in the lymphocyte gate were used for analysis.

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参考文献：

1.The Journal of clinical investigationLoss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms."11-0711 was used in Flow cytometry/Cell sorting to identify pleckstrin-2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced myeloproliferative neoplasms."AuthorsZhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P2.Journal of cellular physiologyLCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment."11071182 was used in flow cytometry to examine the function of lipocalin-2 in bone tissue"AuthorsCosta D,Principi E,Lazzarini E,Descalzi F,Cancedda R,Castagnola P,Tavella S3.PloS oneThe mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria."11-0711 was used in Flow cytometry/Cell sorting to study the mechanistic basis of the Char10 effect."AuthorsLaroque A,Min-Oo G,Tam M,Ponka P,Stevenson MM,Gros P4.Nucleic acids researchIntron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation."Published figure using CD71 (Transferrin Receptor) monoclonal antibody (Product # 11-0711-82) in Flow Cytometry"5.PloS oneThe mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria."11-0711 was used in Flow cytometry/Cell sorting to study the mechanistic basis of the Char10 effect."AuthorsLaroque A,Min-Oo G,Tam M,Ponka P,Stevenson MM,Gros P

技术参数

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