Cytochrome C Monoclonal Antibody (2B5), eBioscience/细胞色素C单克隆抗体（2B5）
货号：BMS1037
规格：100 µg
价格：3679
产品类型：流式抗体
品牌：eBioscience
物种：人
宿主：小鼠
抗体亚型：其它
克隆号：2B5
荧光染料：其它
类型: | 单抗 | 同型对照： | |
浓度： | 1 mg/mL | 用法： | Assay-Dependent（ELISA)；Assay-Dependent(Flow)；Assay-Dependent(IP)；Assay-Dependent(WB) |
产品详细信息Description: Cytochrome c was identified as a component required for the crucial steps in apoptosis, caspase-3 activation and DNA fragmentation. Cytochrome c was shown to redistribute from mitochondria to cytosol during apoptosis in intact cells.Mitochrondrial cytochrome c is a water-soluble protein of 15 kDa with a net positive charge, residing loosely attached in the mitochrondrial intermembrane space. Cytochrome c functions in the respiratory chain by interaction with redox partners.The release of cytochrome c into the cytosol leads to an activation of an apoptotic program via activation of a caspase dependent pathway. Cytochrome c achieves this goal by interaction with other cytosolic factors forming a complex (apoptosome) composed of cytochrome c, Apaf-1, dATP and Apaf-3/caspase 9. Bcl-2 on the other hand was shown to be able to prevent apoptosis by blocking the release of cytochrome c from mitochondria.Applications Tested: ELISA, Flow Cytometry, Western Blotting.靶标信息Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase3, an ICE family molecule that is a key effector of apoptosis.
流式抗体
©
Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://biorod.cn/thread-22727.htm
QQ:1749072012