mTOR Polyclonal Antibody/mTOR多克隆抗体

货号：PA5-34663

规格：100 µL

价格：5853

产品类型：抗体和染料

品牌：Thermo Fisher

抗原：Recombinant fragment corresponding to a region wit

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	多抗	同型对照：
浓度：	0.27 mg/mL	用法：	Assay-dependent(ChIP)；1:100-1:1000(ICC)；1:100-1:1000(IF)；1:100-1:1000(IHC (P))；1:100-1:500(IP)；1:500-1:3000(WB)

产品详细信息Recommended positive controls: 293T, A431, HeLa, HepG2, mouse brain, Flag-human mTOR transfected 293T.Predicted reactivity: Mouse (99%), Rat (100%), Zebrafish (90%), Sheep (98%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.靶标信息Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a key role in cell growth, cell proliferation, and protein synthesis. mTOR mediates phosphoinositide 3-kinase and Akt/PKB signaling, resulting in phosphorylation of 4EBP1, and initiation of mRNA translation. A second pathway involves regulation of ribosomal S6 kinase, which affects ribosome biogenesis and translation elongation. Mutations affecting the gene results in Smith-Kingsmore syndrome.

数据：

mTOR Antibody (PA5-34663) in ICCImmunocytochemistry-Immunofluorescence analysis of mTOR was performed in MCF-7 cells fixed in ice-cold MeOH for 5 min. Green: mTOR Polyclonal Antibody (Product # PA5-34663) diluted at 1:2000. Blue: Hoechst 33342 staining. Scale bar = 10 µm. mTOR Antibody (PA5-34663)Proceedings of the National Academy of Sciences of the United States of America 2016 -Published figure using mTOR polyclonal antibody (Product # PA5-34663)

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参考文献：

1. Nature communicationsInhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.2. Proceedings of the National Academy of Sciences of the United States of AmericaIn situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip.3. Proceedings of the National Academy of Sciences of the United States of AmericaIn situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip.4. Proceedings of the National Academy of Sciences of the United States of AmericaIn situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip.

技术参数

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