Human IL-27 ELISA Kit/人IL-27 ELISA试剂盒
货号：EH271RB,EH271RBX5,EH271RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 81 pg/mL |
| 检测范围 | 81-20,000 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | IL-27 |
| Protein aliases | cytokine receptor, EBV-induced gene 3 protein, Epstein-Barr virus induced gene 3, Epstein-Barr virus-induced gene 3 protein, IL-27 p28 subunit, IL-27 subunit alpha, IL-27 subunit beta, IL-27-A, IL27 subunit, IL27-A, IL35 subunit, interleukin 30, Interleukin-27 subunit alpha, Interleukin-27 subunit beta, Interleukin-30, p28 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | EBI3, IL-27, IL-27A, IL-27B, IL27, IL27A, IL27B, IL27p28, IL30, p28 |
| Gene ID | (Human) 10148,(Human) 246778 |
| Gene symbol | EBI3, IL27 |
| UniProt ID | (Human) Q14213,(Human) Q8NEV9 |
| Human IL-27 quantitates human IL-27 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-27.人IL-27定量检测血清，血浆，上清液中的人IL-27。 该检测试剂盒将只识别天然和重组人IL-27。Target information 靶标信息IL-27 (Interleukin 27) is a cytokine belonging to the IL-12 family, and is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. IL-27 acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting IL-27 involvement in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. In humans, the gene is located on the p arm of chromosome 16.IL-27（白介素27）是属于IL-12家族的细胞因子，是由EBI3和p28亚基组成的异二聚体细胞因子。 IL-27由活化的树突状细胞和巨噬细胞响应Toll样受体配体和促炎性细胞因子产生。 IL-27通过诱导转录因子T-bet的表达和上调IL-12R beta2来促进CD4 + T细胞分化为Th1谱系，进而抑制Th2和Th17的分化和增殖。 IL-27是促炎和免疫调节细胞因子IL-6 / IL-12家族的最新成员。 IL-27通过与其受体WSX-1和gp130结合而起作用，从而导致Jak / STAT信号级联反应的激活，表明IL-27参与了免疫过程的调节。已经提出IL-27还可以用作抗癌的治疗剂，因为它还可以诱导通过CD8 + T细胞，IFN-γ和T-bet介导的肿瘤特异性抗肿瘤活性。在人中，该基因位于16号染色体的p臂上。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。 |
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